The Lewis and Clark Bridge is a bridge that crosses the Ohio River northeast of downtown Louisville, Kentucky and is part of a ring road around the Louisville metropolitan area, connecting two previously disjointed segments of Interstate 265.

It was known as the East End Bridge for 30 years since its conception and while under construction, and renamed by Indiana officials on the day of its opening, December 18, 2016.

[3] The design for what was then known as the East End Bridge is the result of the $22.1 million, four-year Ohio River Bridges Study, which found that solving the region's traffic congestion would require the construction of two new bridges across the Ohio River and reconstruction of the Kennedy Interchange in downtown Louisville.

Construction costs totaled $242 million at the end of January 2017.

[4] On June 4, 2019, the two disjointed sections of I-265 were finally connected under AASHTO approval, with the Indiana State Road 265 designation decommissioned and replaced by I-265.