After the Gentile Reform in 1923, this school became the Regio Liceo Scientifico di Roma,[2] under the royal legislative decree of 9 September 1923, n.

[2] Among the more famous people to have worked here were the poet Margherita Guidacci, English language and literature teacher from 1965 to 1975, Gioacchino Gesmundo, History and Philosophy teacher from 1934 to 1944, and the physicist Bruno Pontecorvo (who was part of the group of physicists and scientists named I Ragazzi di Via Panisperna', 'Via Panisperna Boys') with his younger brother Umberto.

Notable former students include Franca Falcucci, the future Minister of public education,[4] and Marta Russo, whose murder garnered huge media attention.

The building was built between 1884 and 1887 by architect Luca Carimini, and it initially housed the Missionary Oblates of Mary Immaculate college.

[7] On 29 September 2001, to celebrate the 75th anniversary of the school, Poste Italiane issued a postage stamp that portrayed the Liceo.