Limulus clotting enzyme (EC 3.4.21.86, clotting enzyme) is an enzyme.
[1][2] This enzyme catalyses the following chemical reaction: This enzyme is present in the hemocyte granules of horseshoe crabs Limulus and Tachypleus.
In the immunity-related clotting pathways of these organisms, it is the final enzyme responsible for the activation of coagulin.
[3]