Limulus clotting factor overbar C (EC 3.4.21.84, factor C, limulus factor C) is an enzyme.
[1][2][3] This enzyme catalyses the following chemical reaction This enzyme is isolated from the hemocyte granules of the horseshoe crabs Limulus and Tachypleus, where it serves as a LPS endotoxin-sensitive trypsin type serine protease to protect the organism from bacterial infection, initiating a cascade leading to coagulin formation.
[4] From the N-terminus to the C-terminus, the domains are: This enzyme is useful in Limulus amebocyte lysate as the endotoxin-detecting element.
It can be produced recombinantly.
[5]