[5][6] LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4.

[7] The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections.

Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall.

[8] Dietary glucose and saturated fats acutely increase plasma LBP.

[10][11][12] This article incorporates text from the United States National Library of Medicine, which is in the public domain.