Tollip interacts with cellular and subcellular membrane compartments such as endosome and lysosome through its C2 domain binding with phosphoinositides.

[9] By coordinating organelle communications, Tollip can contribute to the fusion of endo-lysosome and autophagosome.

Mice with Tollip deletion exhibit elevated risks for inflammatory diseases such as atherosclerosis and neurodegeneration.

[10] Polymorphisms in TLR genes have been implicated in various diseases like atopic dermatitis.

[11] Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.