[1] She is best known for her roles in English anime adaptations, such as Lina Inverse in Slayers and Amy Rose in Sonic X.

She voiced the latter character in the mainline and spin-off Sonic the Hedgehog video games from 2005 to 2010.

Her first major voice acting role was the Gym Leader Sabrina in the long running Pokémon anime series.

At the 2002 Katsucon in Baltimore, Maryland, Lisa admitted that her start in voice overs came from her brother stealing her car, which led to her meeting a friend to retrieve the car, who then invited her to a casting call for Record of Lodoss War.

Ortiz is the President of Noise of O Productions,[3] LLC, an audio post house and has directed for games and animation, including Modern Combat 5 and Super 4.