Iodine made cameo appearances on October 30, 2022, July 23, 2023, August 13, 2023, and January 28, 2024, in the Popeye Sunday comic strip.

[4] First seen during the 1930s in a supporting role in Hatlo's popular gag panel, They'll Do It Every Time, Little Iodine was the daughter of Henry Tremblechin and his wife, Cora.

Her purpose was to serve as a pesky nuisance to the strip's star, Henry, and her behavior caused endless misery for her mild-mannered, easily unsettled father.

Iodine's antics gave the Sunday comics page a female precursor to Hank Ketcham's Dennis the Menace.

In 1946, Comet Productions, a company established by Mary Pickford, her husband, Charles Rogers and Columbia executive Ralph Cohn, produced a 56-minute feature film, Little Iodine, starring Hobart Cavanaugh as Henry, Irene Ryan as Cora and Jo Ann Marlowe as Little Iodine.