It flooded in 1972 and again in August 2006, and September 2012 reaching a volume of over 4,500 cubic feet per second (130 m3/s), causing minor damage to homes and infrastructure.

The river begins in Hatcher Pass, a state recreation area that was originally opened by hard rock mining.

Mostly characterized by clear cold water flowing over rounded granite boulders and drops of moderate size.

The Alaska Department of Fish and Game operates a weir to count King, Red, Coho, and Chum salmon in the river.

The Little Susitna River weir is located a short distance upstream from the Public Use Area off Burma Road.

Several other less targeted species such as Arctic grayling, burbot, round whitefish and northern pike also call the Little Susitna River home.