Infection most commonly develops after minor scratches or insect bites, but many patients cannot recall any skin trauma.

Lacazia loboi is characterized by long chains of spherical cells interconnected by tubules.

[10] The disease is often misdiagnosed as Blastomyces dermatitidis or Paracoccidiodes brasiliensis due to its similar morphology.

[11] Treatment with antifungals has been considered ineffective, but the use of clofazimine and dapsone in patients with leprosy and lobomycosis has been found to improve the latter.

In January 2006, a potential epidemic of lobomycosis was reported in dolphins of the Indian River Lagoon in Florida.