Lone Horn's sons were Spotted Elk (later known as Big Foot) and Touch the Clouds, Rattling Blanket Woman was his sister, and Crazy Horse was his nephew.

After Lone Horn's death his adopted son Spotted Elk eventually became chief of the Minneconjou and was later killed along with his people at the Wounded Knee Massacre in 1890.

Consumed by sorrow, he committed suicide by attacking a buffalo bull on foot with only a knife, and was mangled to death.

[1] Drury and Clavin's text The Heart of Everything That Is: the Untold Story of Red Cloud states that One Horn's suicide was caused by his grief over the death of his favorite wife: "But when illness took his favorite young wife, so heavy was his grief that in a kind of ritual suicide he attacked a bull buffalo, alone, on foot, with only a knife.

"[4] Lone Horn (c. 1814-1875), son of Red Fish (Oglala), served as head chief of the Miniconjou.