The album contains guest appearances from Lil Durk, late rapper King Von, Booka600, Memo600, Doodie Lo, THF Zoo, Lil Uzi Vert, Chief Wuk, Tee Grizzley, Big30, EST Gee, OTF Timo, Boss Top, C3, Slimelife Shawty, Jusblow600, Lil Mexico, Foogiano, OTF Ikey, Hypno Carlito, Boonie Moe, and Boona.

It is dedicated to him and is not the first time that Lil Durk has dedicated music to the late rapper, as some works include his sixth studio album, The Voice (2020), along with all the songs on the album, specifically the sixth track and their first posthumous collaboration, "Still Trappin'".

[6] On March 2, 2021, the label revealed the blurred track listing along with the announcement of the release of "Jump", performed by Lil Durk, King Von, and Booka600, featuring Memo600.

[7][8] The clear and official track listing was finally revealed the day before the album was released, March 4, 2021.

[11] Loyal Bros debuted at number 12 on the US Billboard 200 chart, earning 28,000 album-equivalent units (including 2,000 copies in pure album sales) in its first week.