Directed by Johnny Manahan, it stars Jolina Magdangal, Claudine Barretto, Camille Prats, Paolo Contis, Gio Alvarez, Rica Peralejo, Roselle Nava, Angelu de Leon, Jan Marini, Kristine Hermosa, Sarah Geronimo, Winnie Cordero, Angelica Panganiban, John Prats, Shaina Magdayao, Geoff Eigenmann, Kaye Abad and Patrick Garcia.

After running on-air for two years, Ang TV came back with a new theme song and a new logo, and the network added more talents to the show's list of bright stars.

Other ABS-CBN shows along with the subsidiaries of the network have picked up on this catchphrase as well (examples: The King of Comedy Dolphy, Bernardo Bernardo, Dang Cruz and Cita Astals from "Home Along Da Riles"; Joey Marquez, John Estrada, Amy Perez, Carmina Villarroel, Cynthia Patag, Gloria Romero and Richard Gomez, The Gwapings:Jomari Yllana, Mark Anthony Fernandez, and Eric Fructuoso, from "Palibhasa Lalake", Aga Muhlach, Jimmy Santos, Babalu, Ching Arellano and Agot Isidro, from "Oki Doki Doc"; Jim Paredes, Gel Santos-Relos and the staff of "Tatak Pilipino"; and Jennifer Sevilla, Noel Trinidad, Joji Isla, Roderick Paulate, Carmi Martin, Tessie Tomas, Nanette Inventor, Nova Villa and Sammy Lagmay from "Abangan ang Susunod Na Kabanata"; Butch Francisco and Cristy Fermin from "Showbiz Lingo"; Anchors of DZMM; DJs of 101.9 Radio Romance; and several ABS-CBN News Personalities).

In homage to Ang TV, Bodie Cruz, as a cast member of the reality show Pinoy Big Brother: Season 2, had to complete a task of beginning each of his sentences with "Esmyuskee" (play with the phrase "excuse me"), and then ending them with "Nge!"

The Esmyuskee skit was also used on Goin' Bulilit, with the Ang TV cast members Angelica Panganiban on September 22, 2013, and Jolina Magdangal on November 16, 2014, as special guests.