He played 2015 with the Dominican Summer League Mariners where he slashed .336/.405/.465 with two home runs, 35 runs batted in, and 19 stolen bases in 60 games, 2016 with the Arizona League Mariners where he hit .239 in 34 games, and started 2017 with the Clinton LumberKings.

On August 6, 2017, the Mariners traded Rengifo along with Anthony Misiewicz and a player to be named later (Osmy Gregorio), to the Tampa Bay Rays for Mike Marjama and Ryan Garton.

[9] On September 16, 2022, Rengifo recorded his first multi-home run game, in an 8–7 home victory over his former organization, the Seattle Mariners.

[12] In 2023, Rengifo enjoyed a career year that saw him play in 126 games and hit .264/.339/.444 with 16 home runs, 51 RBI, and 6 stolen bases.

[14] On September 7, Rengifo suffered a ruptured biceps tendon while in the on–deck circle during a game against the Cleveland Guardians.

[16] Rengifo played in 78 games for Los Angeles in 2024, hitting .300/.347/.417 with six home runs, 30 RBI, and 24 stolen bases.

[17] On September 16, 2021, it was reported that Rengifo had been charged by Venezuelan authorities with forging divorce documents and selling property without his ex-wife's consent.