In 1518 to find Luis de Vega settled in Torrelaguna to take care of the construction of some houses owned by the university.
[2]: 7 Also is 1537, Vega built a manor house, the Palacio de Dueñas, in Medina del Campo for Dr. Beltrán, friend of Cobos.
In December 1537, Vega and Alonso de Covarrubias were appointed to be in charge of the expansion, reconstruction and reform of the fortresses of Madrid, Toledo and Seville, with the obligation that each of the masters reside alternately for six months in them.
While there he directed the construction of the chapel of the bishop of Calahorra, Don Alonso de Castilla Zúniga in the Madrid convent of Santo Domingo, including a new porch.
[1] In 1540 he designed the upper story of the "Patio de las Doncellas" (Courtyard of the Maidens) in the Alcázar of Seville.