Most of the story takes place in Italy and San Marino, although some episodes are partly set elsewhere (e.g., France, Japan), with Lupin wearing a blue jacket.

The English dub, which was directed by Richard Epcar and Ellyn Stern,[15][4] started airing in the United States on Adult Swim's Toonami programming block on June 18, 2017[16] and concluded on January 21, 2018.

According to Anime Limited, these differences in video footage made it "simply not possible to include both language options" in one set.

The series was produced by Telecom Animation Film, with franchise veteran Kazuhide Tomonaga serving as chief director and Yoichiro Yane directing with scripts by Yūya Takahashi.

Tomonaga's aim was to mix the opposing elements of the franchise and combine them into a series that is both hardboiled and comical, realistic and fantastical.

[19] Producer Yû Kiyozono stated that the series was set in Italy due to the success achieved by the Lupin the Third franchise in that country.