With over 5000 passengers per day, it is the most important railway station in the eastern part of the state of Saxony-Anhalt.

The station is located in the east of Wittenberg, about one kilometre from the historic city centre.

It still exists today and is considered one of the oldest railway station building in Germany, but it is no longer used as such.

It was located on the town side of the railway tracks at about the 95.0 km point of the current chainage of the line.

In the spring of 1996, extensive remodelling of the station began as part of the German Unity Transport Projects (Verkehrsprojekts Deutsche Einheit): 8.3 (upgrading of the Berlin–Leipzig/Halle line).

While previously access to the station had only been possible by a road running between the tracks of the lines to Bitterfeld and Dessau, there has since been a direct western exit to the town.

On 7 March 2011, the former Saxony-Anhalt Minister for Construction and Transport, Karl-Heinz Daehre, presented the idea of the first climate-friendly station in Germany.

[4] The entrance building designed by Franz Schwechten and opened in 1877 was built on an island between the tracks.

[10] After the destruction of the Second World War only the outer walls were intact and the design of the entire interior comes from the post-war period.

Wittenberg station offers connections to the north to Berlin as well as to the south towards Halle and Leipzig.

To the west there are regional rail links towards Dessau and from there to Magdeburg and to the east there are connections to Falkenberg (Elster) and from there to Cottbus and Hoyerswerda.