The strong relationship is expressed both bilaterally and through common membership in NATO, OECD, and the OSCE.

The United States, fighting on the Allied side, contributed to Luxembourg's liberation in World War I and World War II.

John Mersch, vice-consul of the United States in Luxembourg, was imprisoned by the German occupiers during World War II in a subcamp of the Hinzert concentration camp in Wittlich.

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