According to her father, Lyodra was able to sing the song "Ibu Kita Kartini" with a better vibrato technique than her peers, even better than those who had taken vocal lessons before.

[16] In 2013, Lyodra studied under Derta Purba, who was also the vocal teacher of the classical singer Putri Ayu Silaen.

When she was still a seventh grader in junior high school, Lyodra imitated Mariah Carey's use of the whistle register in the song "O Holy Night".

[25] In 2021, Lyodra attended the Pelita Harapan University and majored in communication studies but resigned at the end of second semester.

In the final round at the national level which was held on 31 March 2014, at Djakarta Theater XXI, Central Jakarta, Lyodra took to the top four position and took home the first consolation prize in the form of cash worth 25 million rupiah.

[28] On 1 August 2014, Lyodra appeared as a participant in season 4 of Indonesia Mencari Bakat, which aired on the national television station Trans TV.

[30] Lyodra's joining of DARR 2 has made her involved in various large-scale musical performances, one of which was the Java Jazz Festival 2016 which was held throughout the 4–6 March at JIExpo Kemayoran, Jakarta.

During the audition she performed Lady Gaga's song "I'll Never Love Again", and with her usage of the whistle register impressing the judges resulted in her reception of a golden ticket.

[42][43] From Indonesian Idol, Lyodra received a song entitled "Gemintang Hatiku" as her prize, which became her first single as an adult singer.

[45] On 14 February 2021, a seven-episode teen drama web series, 7 Hari Sebelum 17 Tahun, aired on the media service provider application for the digital channel Stro, in which Lyodra made her acting debut in as an antagonist named Gina, a temperamental high school student.

[49] In this eponymous album, she collaborated with a number of musicians who act as composers and producers, most prominently Dipha Barus, Ade Nurulianto, Anji, Yovie Widianto, Mario Gerardus Klau, Tohpati, and Laleilmanino.

[52] In October 2021, Lyodra was nominated as "Best Southeast Asian Act" from the 2021 MTV Europe Music Awards held on 14 November 2021, at the László Papp Budapest Sports Arena in Budapest, Hungary after being defeated by JJ Lin from Singapore in the online voting on the official website MTV Europe Music Awards.

In November 2021, Lyodra was the performer of Indonesia's National Day in the series of Expo 2020 at Al Wasl Plaza, Dubai, with notable attendance by President Joko Widodo and Crown Prince of Abu Dhabi, Prince Mohammed bin Zayed Al Nahyan.

Due to the success of her solo album, Lyodra was highlighted by Spotify as Artist of the Month for the November 2021 period from Indonesia in the context of the Equal campaign program.

In the campaign, Lyodra's photo was chosen to be placed on a Times Square digital billboard in New York City, United States.

Calum Scott sings this song in a duet with 4 singers from Southeast Asia, with collaborations with Lyodra (Indonesia), Diana Danielle (Malaysia), Darren Espanto (Philippines), and Hoàng Duyên (Vietnam).

On 7 June 2022, through the official Instagram page of Idola Cilik, Lyodra was chosen to be one of the guest judges in the talent search event with Judika and Aurel Hermansyah.

On 12 August 2022, Lyodra released a single with Andi Rianto entitled "Sang Dewi", which is a remake of Titi DJ's original version in 2001 .

Lyodra is known to be fond of Agnez Mo's works, including "Rindu", "Matahariku", "Karena Ku Sanggup", and "Jera".

[60] In addition, other singers such as Raisa, Rossa, Judika, Once Mekel, Dua Lipa, and Billie Eilish also indirectly influenced her musical style.