Lyon is a town in Coahoma County, Mississippi, United States.

According to the United States Census Bureau, the town has a total area of 0.46 square miles (1.2 km2), all land.

The racial makeup of the town was 74.40% White, 25.12% African American and 0.48% Asian.

The town of Lyon is served by the Coahoma County School District.

[9] Tennessee Williams grew up in neighboring Clarksdale and referred to the town in his poem The Couple: I saw them often when they drove to Lyons, a ghostly pair perched on a wooden scaffold.