The Lytle Tunnel is a vehicular tunnel that carries Interstate 71 (I-71) under the historic Lytle Park in Cincinnati, in the U.S. state of Ohio, connecting Fort Washington Way to the Northeast Expressway.

During the construction of the Lytle Tunnel, many historic buildings were razed for the project.

A few of the original buildings remain, including the Literary Club of Cincinnati, the Anna Louise Inn, Guilford School building, and the Phelps Apartments.

A CB radio broadcast on channel 19, the most commonly used commercial trucking frequency, loops a warning about this turn and its hazards 24 hours a day, seven days a week.

Immediately after construction of the Lytle Tunnel, the 550 E Fourth Street apartments (2 buildings) and were built on air rights over the tunnel along with the reconstruction of Lytle Park, which became the first park built over an interstate highway.