There are seven genes: The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.
[1] The acronym MEK derives from MAPK/ERK Kinase.
[2] MEK is a member of the MAPK signaling cascade that is activated in melanoma.
[3] When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced.
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