This kinase specifically interacts with and activates MAPK7/ERK5.

The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation.

Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

MAP2K5 has been shown to interact with MAPK7,[5] MAP3K2,[7] Protein kinase Mζ[8] and MAP3K3.

This article on a gene on human chromosome 15 is a stub.