This kinase binds to TRAF2 and stimulates NF-κB activity.

It is a critical kinase of the alternative NF-κB activation pathway.

It shares sequence similarity with several other MAPKK kinases.

It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

This article on a gene on human chromosome 17 is a stub.