This kinase has been shown to directly phosphorylate and activate IkappaB kinases, and thus plays a role in NF-kappa B signaling pathway.

This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

[7] MEKK2 is activated through homodimerization and subsequent trans-autophosphorylation at MEKK2-S519.

[8][9] MEKK2 is regulated by 14-3-3 proteins which bind to MEKK2-phosphoT283.

This article on a gene on human chromosome 2 is a stub.