Its catalytic domain is closely related to those of several other kinases, including mouse MEKK2, tobacco NPK, and yeast STE11.

Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed.

In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NF-κB)-dependent reporter gene, consistent with a role in the SAPK pathway.

Alternatively spliced transcript variants encoding distinct isoforms have been observed.

[7] MAP3K3 has been shown to interact with [SQSTM1/p62],: Two SNPs in the MAP3K3 gene were found as candidates for association with colon and rectal cancers.