855017165ENSG00000089022ENSMUSG00000029454Q8IW41O54992NM_001371482NM_001371483NM_001371484NM_001371485NM_001371486NM_001371487NM_010765NP_001358411NP_001358412NP_001358413NP_001358414NP_001358415NP_001358416NP_034895MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene.

[5][6] The protein encoded by this gene is a member of the serine/threonine kinase family.

In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites.

Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

[6] A link between Alzheimer's disease and reduced levels of MAPKAPK5 has been proposed.