1IWQ408217118ENSG00000277443ENSMUSG00000069662P29966P26645NM_002356NM_008538NP_002347NP_032564Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the MARCKS gene.

[8] Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin.

They are regulated by Ca2+/calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2.

Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm.

The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.