Roy Halladay of the Philadelphia Phillies is the cover athlete of the game replacing Gold Glove Award winner Evan Longoria from MLB 2K10.

Base stealing has been revamped, and will take into account many variables such as the speed of the runner, type of pitch, lead, and the catcher's arm.

[3] The Wii version has its own unique features, including the Mini-Diamond, a new multiplayer mode set in fantasy venues, such as a low gravity Space ballpark to a Circus environment, while the Total Control Pitching and Hitting feature utilizes the Wii Remote and Nunchuk.

The PlayStation 2 and PlayStation Portable versions are less feature-rich than the main version as they are reskins of Major League Baseball 2K6, but they still feature Franchise and Season play, the Home Run Derby and a unique Manager Showdown feature in which a player sets up a lineup and a starting pitcher and plays the game strictly from the manager's role as strategist.

The PSP version adds The Farm, which allows the player to engage in Minor League Baseball games.

This caused controversy as former WWE wrestler Stevie Richards had done this before and tried to claim the million dollars for the perfect game he had pitched but had done it before the contest officially began.

[4] Brian Kingrey, a music teacher from Hammond, Louisiana, claimed the prize by throwing a perfect game with Roy Halladay within two hours of the start of the contest.

Finally, the relief pitcher is often allowed to bat, even though they are going to be replaced in the next inning and the bench is full of potential batters.