3BGV, 3EPP, 5E9J, 5E9W, 5E8J873167897ENSG00000101654ENSMUSG00000009535O43148Q9D0L8NM_001308263NM_003799NM_001378132NM_001378134NM_001378135NM_001170953NM_026440NM_001361002NM_001361003NP_001295192NP_003790NP_001365061NP_001365063NP_001365064NP_001164424NP_080716NP_001347931NP_001347932In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.
In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.
[5][6][7] The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase.
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