Magdalena Mixtepec is a town and municipality in Oaxaca in south-western Mexico.

It is part of the Zimatlán District in the west of the Valles Centrales Region.

A civil congregation existed in the town around the turn of the 16th and 17th centuries.

[1] The town was previously known as Magdalena Tepex Zimatlán, but was renamed as the parish of Santa Cruz de Mixtepec.

[3] There are a handful of the near-extinct Asunción Mixtepec Zapotec language speakers remaining in the town.