Santa Cruz Mixtepec is a town and municipality in Oaxaca in south-western Mexico.

The town covers an area of 66.34 km².

It is part of the Zimatlán District in the west of the Valles Centrales Region In 2005, the municipality had a population of 2,984.

[1] The church is notable for a number of colonial-era santos or statues of the saints, many of them executed in fine polychrome that has been well preserved.

[2] This article about a location in the Mexican state of Oaxaca is a stub.