The Main Street Museum is an eclectic display space for material culture and a civic organization in White River Junction, Vermont.

However, the Museum also focuses on new technology, notably cataloging its collections and conducting online activity through its Wiki (see below).

The Main Street Museum was founded in 1992 by David Fairbanks Ford in an area of White River Junction known as the Old South End.

Categories include: Flora; Fauna; significant objects from around the world; evidence of tramps; Round Things; Tangled Things; journals; extraneous bits of local history; sheet music; postcard collections; electromagnetism devices; relics from the head injury of Phineas Gage; Elvis impersonators; live music; taxidermy and biological anomalies (dehydrated cats).

Described by the Washington Post as "quirky and avant-garde", a heterodox assortment of the local public, scholars, musicians, artists, historians, scientists, drunks and all other types of people have been drawn to the museum's unusual demonstrations, lectures and entertainments.