Later that year, they were repackaged and renamed to Curt Hawkins and Zack Ryder as associates of Edge and subsequently aligned themselves with La Familia on the SmackDown brand.

[8] On September 23 they were entered into a three-way match with the champions but Team Tremendous (Dan Barry and Ken Scampi) ended up with the belts.

They picked up their first wins on June 15 against Francisco Ciatso and Cru Jones but lost a Four Way title contendership match in July to Urban Assault (Peréz and Sonny Siaki).

[10] Their rematch went to a no contest when Urban Assault's manager G-Rilla began fighting with The Freakin' Deacon who was in The Majors' corner.

[10] The Majors stayed in DSW until April, exchanging victories with The Blue Bloods and teaming with Kofi Nahaje Kingston to defeat The Next Generation Hart Foundation (Harry Smith and TJ Wilson) and Shawn Osborne.

[11] Brian Majors pre-empted the tag team's first appearance in Ohio Valley Wrestling (OVW) on April 25's TV tapings in a 15-minute time limit draw against Jay Bradley.

As a team they debuted on May 9 to pick up a win against Los Locos (Ramon and Paul) with a slightly tweaked name of The Major Brothers.

After defeating Gothic Mayhem (Johnny Punch and Pat Buck) in successive matches they went on to defeat the reigning OVW Southern Tag Team Champions "The Hammer" Charles Evans and "The Ox" Justin LaRouche (future La Familia stablemate Bam Neely) twice in non-title matches, once by disqualification.

They continued to win in a Four Corners Tag Team match against Los Locos, The Empire and LaRouche with Andrew Vain.

[12] The Major Brothers made their WWE television debut on the May 1, 2007 episode of ECW on Sci Fi defeating Matt Striker and Marcus Cor Von in a tag team match.

[20] After a loss to Deuce 'n Domino on August 17, 2007, The Majors would not compete on the show again until October 12, 2007, when the debuting Drew McIntyre defeated Brett.

[23] On November 9, 2007, they received a tag title match after winning a number one contender's battle royal, but could not defeat the champions, Montel Vontavious Porter and Matt Hardy.

[26] Occasionally teaming with their mentor Edge and/or their "La Familia" associate Chavo Guerrero on SmackDown, they even went on to be featured in the main event on multiple occasions.

On the November 14, 2018 edition of WWE Main Event, Hawkins and Ryder teamed up for the first time since 2011 in a loss to Apollo Crews and Tyler Breeze.

[37] On April 5, WWE announced that Hawkins and Ryder would face The Revival at WrestleMania 35 for the Raw Tag Team Championship.

[38][39] At the event's Kickoff Show, the duo won the Raw Tag Team Championships, subsequently breaking Hawkins' 269-match losing streak.

[40] At The Shield's Final Chapter, Hawkins and Ryder once again successfully defended the belts against The Revival and Aleister Black and Ricochet in a triple threat match.

[44] On April 15, 2020, Curt Hawkins and Zack Ryder were released from their WWE contracts as part of budget cuts due to the COVID-19 pandemic.