Makrinou (Greek: Μακρινού) is a village and a community in the municipal unit of Makryneia, Aetolia-Acarnania, Greece.

The community includes the villages Agia Triada, Agioi Apostoloi, Kypseli and Metaxas.

It is located on a mountainside southeast of Lake Trichonida.

Makrinou is 2 km southwest of Kato Makrinou, 10 km southeast of Gavalou, and 21 km northwest of Naupactus.