Since the 2011 local government reform it is part of the municipality Agrinio, of which it is a municipal unit.

The municipal unit is located south and southeast of Lake Trichonida, and northwest of the mountain Arakynthos.

There are farmlands near the lake shore, and forests on the mountain slopes.

Makryneia is southeast of Agrinio, northeast of Missolonghi and northwest of Naupactus.

The municipal unit Makryneia is subdivided into the following communities (constituent villages in brackets):