Mangafodipir (sold under the brand name Teslascan as mangafodipir trisodium) is a contrast agent delivered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver, and has potential to serve as an adjunct for various chemotherapeutic agents and during coronary intervention.
It has two parts, a paramagnetic manganese(II) ion and the fodipir (dipyridoxyl diphosphate, DPDP) chelating agent.
When freed from the organic ligand, the manganese shortens the longitudinal relaxation time (T1) in an MRI scan.
Mitochondrial manganese superoxide dismutase (MnSOD) normally keeps ROS and RNS in check.
During development of mangafodipir as an MRI contrast agent, it was discovered that it possessed MnSOD mimetic activity.