Situated at the river's mouth, near the shore of Lake Winnipeg, is the community of Manigotagan.

[5] The last southern herd of woodland caribou in Canada can be found near this river and in Nopiming Provincial Park.

Logging roads and overdevelopment can potentially threaten the important habitat and ecology of this area.

The river is protected in the Manigotagan River Provincial Park (which was designated as a provincial park by the Government of Manitoba in 2004[6]) and Nopiming Provincial Park in Manitoba, as well as the Eagle-Snowshoe Conservation Reserve in Ontario.

This article related to a river in Manitoba, Canada is a stub.