It is a short east-west route starting at PR 259 at Wheatland, east through Rivers, and terminating at PTH 10 six kilometres (3.7 mi) north of Forrest.

PTH 25 begins in the Rural Municipality of Riverdale at a junction with PR 259 in Wheatland, directly north of the former CFB Rivers.

It heads north for roughly 1 kilometre (0.62 mi) before curving eastward, becoming concurrent (overlapped) with PR 250 and crossing a rail line into the town of Rivers.

The highway curves southeast, following First Avenue as it travels through neighborhoods and along the southern edge of downtown, where PR 250 splits off and heads north along Brunswick Street.

The highway travels along the southern edge of Chimo Resort before continuing due east through farmland for several kilometers.