PR 355 begins at the east boundary of the Birdtail Sioux First Nation, and terminates at PTH 16A in Minnedosa.

From Birdtail Sioux First Nation, it travels 8 kilometres (5.0 mi) before it intersects PTH 83 just north of Beulah.

From the end of this second concurrence, the road continues east for 13 kilometres (8.1 mi) to an intersection with PR 270 near the unincorporated community of Cadurcis.

PR 355 continues east for 3 kilometres (1.9 mi) into Minnedosa, reaching its eastbound terminus with PTH 16A in the town's north end.

[2] Prior to this, the road's westbound terminus was at PTH 83, making the original length 90 kilometres (56 mi).