Provincial Road 452 (PR 452) is a 36.4-kilometre-long (22.6 mi) north-south highway in the Westman Region of Manitoba.

It heads due north out of town as a paved two-lane highway, traveling through farmland and rural areas for several kilometers.

After joining PTH 3 (Boundary Commission Trail) westbound, the two run concurrently for 3.3 kilometres (2.1 mi) before turning north along the border with the Municipality of Two Borders, bouncing back and forth between asphalt and gravel sections to enter Napinka at a railway crossing.

The highway has an intersection with Railway Avenue, which leads into downtown, before becoming fully paved again as it makes a sharp left turn at an intersection with Dufferin Avenue (former PR 447 eastbound, leads to PR 254).

Leaving town, PR 452 crosses a bridge over the Souris River before turning to gravel and heading due west through rural farmland, coming to an end shortly thereafter at an intersection with PTH 83, just north of Melita.