The highway heads east to bypass Pierson to the north, where it has a short concurrency (overlap) with PR 256 and crosses a railway line.

PR 452 joins PTH 3 in a concurrency for roughly 4 kilometres (2.5 mi) before splitting and heading south towards Waskada.

The highway now shares a roughly 8-kilometre-long (5.0 mi) concurrency with PTH 21 before splitting off at Deloraine, though it mainly bypasses the town along its western and southern sides.

The highway crosses into the Municipality of Killarney-Turtle Mountain shortly thereafter, having a junction with PR 346 near Ninga before entering the town of Killarney.

[5] PTH 3 now goes through some switchbacks as it crosses the Pembina River valley, having a short concurrency with PR 242 in the town of La Rivière.

The highway leaves the river valley behind and heads due east to Manitou, where it has an intersection with PR 244 and starts paralleling a railroad.

It makes a short jog to the south for a couple kilometres before curving back eastward to have an intersection with PR 528.

Provincial Road 450 (PR 450) is a 19.8-kilometre-long (12.3 mi) north-south spur of PTH 3 in the Municipality of Deloraine-Winchester providing access to the Lake Metigoshe Recreation Area, as well as some other smaller lakes on the western half of Turtle Mountain and the Turtle Mountain Bible Camp, coming within 0.2 kilometres (0.12 mi) of the United States border.

Provincial Road 528 (PR 528) is a 8.2-kilometre-long (5.1 mi) north-south spur of PTH 3 in the Municipality of Pembina, connecting it with the hamlet of Kaleida.