The Manulife Centre is located on the southeast corner of Bay and Bloor streets, along the Mink Mile and adjacent to the southern edge of the Yorkville district of Toronto, Ontario, Canada.

Designed by the Toronto architectural firm of Clifford and Lawrie Architects, construction began in 1970 and was completed in 1974.

Bay Bloor Radio, which was founded in 1946, moved into the Manulife Centre when it opened and remains there today.

Manulife Centre is home to Canada's first flagship Eataly location as well as Over the Rainbow, a fashion retailer, and Shoppers Drug Mart.

Tunnels from the Manulife Centre provide access to Toronto's busiest subway station Bloor–Yonge.