[1] Márquez is often considered one of the greatest innovators of modern MotoGP racing,[2] due to his comparatively exaggerated cornering technique of leaning so far over the bike, that he seems to be "in constant danger of sliding out".

[14] He was less successful in the following races, dropping to third in the standings at one point behind Nicolás Terol and Pol Espargaró after being involved in an accident with Randy Krummenacher at the first corner at the Aragon Grand Prix.

[16] He would fall short of tying it, as he was fourth at the final race in Valencia to become the second-youngest World Champion after Loris Capirossi, winning the smallest category at just 17 years and 263 days.

[5][6] Márquez moved into the Moto2 class for 2011, the first of an expected two-year deal,[17] as the sole rider of the new team Monlau Competición, run by his manager Emilio Alzamora.

[18] At his home race in Catalonia, Márquez finished second behind championship leader Stefan Bradl, before another fall at the Silverstone, having started from his first Moto2 pole position.

[27] Márquez attended the final race of the season in Valencia, in the hope of being fit to compete, but withdrew due to his continued vision problems, giving Bradl the title.

On 12 July 2012, it was announced that Márquez had signed a two-year contract with the Repsol Honda team in MotoGP, replacing the retiring Casey Stoner and joining teammate Dani Pedrosa, from 2013 onwards.

Márquez suffered a bad start to the race and spent many laps in the lower half of the top 10 however by mid-race he began to find his rhythm and progressed forward.

After an average start he worked his way to the front to lead by the end of lap five and was never again headed despite a strong late race charge from Cal Crutchlow to win by 1.5 seconds.

The pair proceeded to swap places on various occasions, with the final pass coming at Turn 3 with just under four laps to go; Márquez became the first rider to win four consecutive races since Valentino Rossi in 2008.

[63] With a tenth successive victory coming at Indianapolis, Márquez became the third rider to achieve such a feat in the premier class, after Mick Doohan and Giacomo Agostini.

[66] At Misano, Márquez crashed while battling for the race lead with Valentino Rossi; he remounted and – with a last-lap retirement for Aleix Espargaró – was able to score one championship point.

[9][70] At Phillip Island, Márquez took his 12th pole position of the season, matching Casey Stoner's record from 2011, but he crashed out while leading the race,[71] his first non-finish since the 2013 Italian Grand Prix.

[94] The first European race was held in Jerez in Spain was the first real test of Márquez' new mentality of patience and he proved it by finishing third in his home Grand Prix behind Yamaha men Rossi and Lorenzo.

Le Mans was not a good race for Márquez, as his Honda suffered from a lack of acceleration leading him to push in the braking zones to try remain in the podium battle.

[97] Márquez finished the 2016 season with a second place at the Valencian Community motorcycle Grand Prix, after struggling to get past the likes of Valentino Rossi and Andrea Iannone in the first part of the race.

He started the year off by narrowly falling short of Andrea Dovizioso off the final corner in Qatar, before a controversial performance resulting in three penalties and causing Valentino Rossi to crash led to Márquez being stripped of a fifth-place finish in Argentina.

Following the British event being cancelled due to dangerous track conditions, Ducati took the third consecutive win at Misano with Dovizioso leading Márquez across the line.

[99] Recovering from a shoulder surgery, Márquez had a compromised pre-season, but still managed to take the Qatar opener to the final corner, where he ultimately fell short to Dovizioso for a second consecutive time.

With his four closest rivals being taken out at once, Márquez controlled the race and won with a sizeable margin, his second career win at his home region's Grand Prix.

Márquez took his 50th career MotoGP win at the Czech round after a pole position by 2.5 seconds in tricky half-wet conditions and leading the race from start to finish.

After missing the opening two races held in Qatar, he announced his return ahead of the Portuguese Grand Prix in Portimão, ending in a seventh place, taking nine points.

After a ninth place finish in Jerez, Márquez suffered three consecutive DNFs (including one in Le Mans, where he had found himself leading the race in rainy conditions).

[123] At the second round after the summer break at the 2023 Austrian motorcycle Grand Prix, Márquez ended his 7-race long streak of non-finishes in main races, finishing in 12th place.

Following his desire to part from Honda at the end of the 2023 season, he joined the Ducati satellite team on a one-year contract,[125] replacing Fabio Di Giannantonio and partnered by his younger brother, Álex Márquez.

[146] On 5 June 2024, it was announced that Márquez will race alongside the two-time World Champion Francesco Bagnaia in the Factory Ducati Team, replacing outgoing Enea Bastianini, who signed for Red Bull KTM Tech3 for 2025,[147] and beating Jorge Martín to the seat as he defects to Aprilia.

Márquez' father Julià has followed him around the world in his team garage and is a permanent fixture in the Grand Prix paddock, while his mother's appearances are rare.

[167] His official fanclub is also located in Cervera, chaired by his uncle Ramón, adjacent to an exhibition at the town museum where memorabilia including championship-winning bikes are displayed.

As of October 2018 on the day of his fifth MotoGP title, Márquez had close to 4 million Facebook followers, being one of the largest motor racers and Spanish athletes on the platform.

[174][175][176] Freddie Spencer, Takazumi Katayama, Randy Mamola, Wayne Gardner, Mick Doohan, Daryl Beattie, Àlex Crivillé, Tadayuki Okada Valentino Rossi, Tohru Ukawa, Nicky Hayden, Dani Pedrosa, Andrea Dovizioso, Casey Stoner, Marc Márquez 1949  L. Graham 1950  U. Masetti 1951  G. Duke 1952  U. Masetti 1953  G. Duke 1954  G. Duke 1955  G. Duke 1956  J. Surtees 1957  L. Liberati 1958  J. Surtees 1959  J. Surtees 1960  J. Surtees 1961  G. Hocking 1962  M. Hailwood 1963  M. Hailwood 1964  M. Hailwood 1965  M. Hailwood 1966  G. Agostini 1967  G. Agostini 1968  G. Agostini 1969  G. Agostini 1970  G. Agostini 1971  G. Agostini 1972  G. Agostini 1973  P. Read 1974  P. Read 1975  G. Agostini 1976  B. Sheene 1977  B. Sheene 1978  K. Roberts 1979  K. Roberts 1980  K. Roberts 1981  M. Lucchinelli 1982  F. Uncini 1983  F. Spencer 1984  E. Lawson 1985  F. Spencer 1986  E. Lawson 1987  W. Gardner 1988  E. Lawson 1989  E. Lawson 1990  W. Rainey 1991  W. Rainey 1992  W. Rainey 1993  K. Schwantz 1994  M. Doohan 1995  M. Doohan 1996  M. Doohan 1997  M. Doohan 1998  M. Doohan 1999  À. Crivillé 2000  K. Roberts Jr. 2001  V. Rossi 2002  V. Rossi 2003  V. Rossi 2004  V. Rossi 2005  V. Rossi 2006  N. Hayden 2007  C. Stoner 2008  V. Rossi 2009  V. Rossi 2010  J. Lorenzo 2011  C. Stoner 2012  J. Lorenzo 2013  M. Márquez 2014  M. Márquez 2015  J. Lorenzo 2016  M. Márquez 2017  M. Márquez 2018  M. Márquez 2019  M. Márquez 2020  J. Mir 2021  F. Quartararo 2022  F. Bagnaia 2023  F. Bagnaia 2024  J. Martín 1949  B. Ruffo 1950  D. Ambrosini 1951  B. Ruffo 1952  E. Lorenzetti 1953  W. Haas 1954  W. Haas 1955  H. Müller 1956  C. Ubbiali 1957  C. Sandford 1958  T. Provini 1959  C. Ubbiali 1960  C. Ubbiali 1961  M. Hailwood 1962  J. Redman 1963  J. Redman 1964  P. Read 1965  P. Read 1966  M. Hailwood 1967  M. Hailwood 1968  P. Read 1969  K. Carruthers 1970  R. Gould 1971  P. Read 1972  J. Saarinen 1973  D. Braun 1974  W. Villa 1975  W. Villa 1976  W. Villa 1977  M. Lega 1978  K. Ballington 1979  K. Ballington 1980  A. Mang 1981  A. Mang 1982  J. Tournadre 1983  C. Lavado 1984  C. Sarron 1985  F. Spencer 1986  C. Lavado 1987  A. Mang 1988  S. Pons 1989  S. Pons 1990  J. Kocinski 1991  L. Cadalora 1992  L. Cadalora 1993  T. Harada 1994  M. Biaggi 1995  M. Biaggi 1996  M. Biaggi 1997  M. Biaggi 1998  L. Capirossi 1999  V. Rossi 2000  O. Jacque 2001  D. Kato 2002  M. Melandri 2003  M. Poggiali 2004  D. Pedrosa 2005  D. Pedrosa 2006  J. Lorenzo 2007  J. Lorenzo 2008  M. Simoncelli 2009  H. Aoyama 2010  T. Elías 2011  S. Bradl 2012  M. Márquez 2013  P. Espargaró 2014  T. Rabat 2015  J. Zarco 2016  J. Zarco 2017  F. Morbidelli 2018  F. Bagnaia 2019  Á. Márquez 2020  E. Bastianini 2021  R. Gardner 2022  A. Fernández 2023  P. Acosta 2024  A. Ogura 1949  N. Pagani 1950  B. Ruffo 1951  C. Ubbiali 1952  C. Sandford 1953  W. Haas 1954  R. Hollaus 1955  C. Ubbiali 1956  C. Ubbiali 1957  T. Provini 1958  C. Ubbiali 1959  C. Ubbiali 1960  C. Ubbiali 1961  T. Phillis 1962  L. Taveri 1963  H. Anderson 1964  L. Taveri 1965  H. Anderson 1966  L. Taveri 1967  B. Ivy 1968  P. Read 1969  D. Simmonds 1970  D. Braun 1971  Á. Nieto 1972  Á. Nieto 1973  K. Andersson 1974  K. Andersson 1975  P. Pileri 1976  P. Bianchi 1977  P. Bianchi 1978  E. Lazzarini 1979  Á. Nieto 1980  P. Bianchi 1981  Á. Nieto 1982  Á. Nieto 1983  Á. Nieto 1984  Á. Nieto 1985  F. Gresini 1986  L. Cadalora 1987  F. Gresini 1988  J. Martínez 1989  À. Crivillé 1990  L. Capirossi 1991  L. Capirossi 1992  A. Gramigni 1993  D. Raudies 1994  K. Sakata 1995  H. Aoki 1996  H. Aoki 1997  V. Rossi 1998  K. Sakata 1999  E. Alzamora 2000  R. Locatelli 2001  M. Poggiali 2002  A. Vincent 2003  D. Pedrosa 2004  A. Dovizioso 2005  T. Lüthi 2006  Á. Bautista 2007  G. Talmácsi 2008  M. Di Meglio 2009  J. Simón 2010  M. Márquez 2011  N. Terol 2012  S. Cortese 2013  M. Viñales 2014  Á. Márquez 2015  D. Kent 2016  B. Binder 2017  J. Mir 2018  J. Martín 2019  L. Dalla Porta 2020  A. Arenas 2021  P. Acosta 2022  I. Guevara 2023  J. Masià 2024  D. Alonso