The Margaret Pendergast House is a home in Savannah, Georgia, United States.

In a survey for the Historic Savannah Foundation, Mary Lane Morrison found the building to be of significant status.

[3] At the age of 16, she married Pierce Butler Pendergast on February 6, 1834, at the Lutheran Church of the Ascension.

[3] Living at 20 East St. Julian Street, they had two children: Margaret Ann and Susan Robertson.

It is not known where her husband was buried, but it is possible his body was lost during the transition of the Old Brick Cemetery to Laurel Grove.