[1] In the late 1860s New Orleans suffered from an outbreak of yellow fever, which killed two of the church's priests.

In 1873 a chapel was built and dedicated to St. Roch, whom the congregation credited with ending the outbreak.

[1] Holy Trinity opened a Catholic School in 1871, run by sisters of the Benedictine order.

[3] In 2011 the church building was bought by Dave Hulbert and Scott King, who converted it into a performing arts venue, and renamed it as the Marigny Opera House.

It is supported by the Marigny Opera House Foundation, a non-profit organization.

[5] In 2013, Depeche Mode used the Marigny as a set for the music video for their song "Heaven".