Mark S. Boguski (died March 18, 2021)[1][2] was an American pathologist specializing in computational analysis and structural biology.

[citation needed] Boguski served on the faculties of the National Institutes of Health, the Johns Hopkins University School of Medicine, Harvard Medical School, and as an executive in the biotechnology and pharmaceutical industries.

In 2014, he became the chief medical officer of Liberty BioSecurity, LLC and founded the Precision Medicine Network.

He previously served as editor-in-chief of Genomics and has written a series of books titled Reimagining Cancer.

One database effort in particular, the database of Expressed Sequence Tags (dbEST,[8] 1993), has contributed to gene discovery and succeeding generations of genomics applications for transcript mapping, design and construction of microarrays, in silico discovery of single nucleotide polymorphisms and analysis and annotation of the human genome.