MD 725 provides access to U.S. Route 301 (US 301, Robert Crain Highway) to the east and forms the Main Street of Upper Marlboro to the west.

MD 202 expands to a four-lane divided highway southeast of its junction with the eastern end of MD 193 (Watkins Park Drive) and crosses the Western Branch into the suburb of Kettering, the site of the historic home Mount Lubentia.

The latter road leads through the eponymous suburb; the former road leads to The Boulevard at the Capital Centre, the Downtown Largo station at the eastern terminus of the Washington Metro's Blue and Silver lines, and Northwest Stadium, the home of the Washington Commanders of the National Football League.

[1][2] MD 202 reduces to six lanes just east of its partial cloverleaf interchange with Interstate 95 (I-95)/I-495 (Capital Beltway).

The highway passes south of the remains of Landover Mall and intersects Brightseat Road, which is unsigned MD 202E and provides northern access to FedExField.

Immediately to the west of the railroad crossing is MD 202's junction with US 50 (John Hanson Highway), which is a combination of the partial cloverleaf and trumpet interchanges.

The highway continues along the northern edge of the town of Cheverly and has a four-ramp partial cloverleaf interchange with the Baltimore–Washington Parkway, which is unsigned MD 295.

This relocation bypassed what is now Old Landover Road and included a bridge across the railroad that now carries the southbound lanes of the highway.

[10] In 1944, the War Production Board authorized the replacement of MD 202's timber bridge across the right-of-way of the abandoned Washington, Baltimore and Annapolis Electric Railway—which was transformed into MD 704—as one of the few non–war-effort highway projects federally funded during World War II.

[21] The divided highway was extended to the Western Branch east of White House Road in 1993 and to its present extent south of MD 193 in 1999.