The state highway runs 10.03 miles (16.14 km) between intersections with MD 349 near Bivalve on the west and near Quantico on the east.

The Whitehaven Road portion of MD 352 was constructed as a state highway from Catchpenny west to Green Hill Creek in the early 1930s.

The state highway heads southeast as two-lane undivided Capitola Road.

MD 352 passes by the historic Yellow Brick House and farmland before veering east at Trinity Church Road, which leads to Ellis Bay Wildlife Management Area.

MD 352 turns north onto Whitehaven Road and passes St. Bartholomew's Episcopal Church.