Known as Mount Hermon Road, the state highway runs 11.80 miles (18.99 km) from Main Street in Salisbury east to MD 354 in Powellville.

MD 350 provides access to a large area of farmland and forest in southeastern Wicomico County as well as Salisbury–Ocean City–Wicomico Regional Airport.

MD 350, which is maintained by the city of Salisbury for its first 0.18 miles (0.29 km), heads east as a four-lane undivided highway, passing north of Wicomico High School.

After the intersection with Beaglin Park Drive, a county arterial highway on the east side of Salisbury, MD 350 veers away from US 50 Business and reduces to a two-lane road.

[6] A small segment in Powellville and the section between Mount Hermon and Sixty Foot Road were completed by 1933.